A nursery for ticks.

Japanese Barberry, also known as Berberis Thunbergii, is a popular plant for landscaping because of its ability to provide privacy and responds well to pruning. Although this plant is beautiful, it is a nursery for ticks. It has  been banned in 5 different states: Maine, Minnesota, New Hampshire, New York, and now in Pennsylvania.

Barberry plants originated from Eastern Asia. It was then imported in 1875 from Russia to Arnold Arboretum in Boston. Since then this bush has then spread north to Nova Scotia, south to North Carolina, and east to Montana, and has flourished as a plant for landscaping.

The leaves in the Japanese Barberry are oval shaped with smooth edges. Most of the time the leaves will be a burgundy color, but they may turn green if they do not receive enough sunlight. This bush can grow up to 2-8 feet high and once the stem touches the ground it can start to grow roots. Barberry plants are known to be very resilient, and are drought tolerant. The germination rate of the seeds are 90% and can also remain dormant for up to 10 years. You can easily identify this plant in the early spring because it will be one of the very first plants to appear. There are huge spines on the branches of the plant that keep unwanted guests away. Since Barberry bushes can multiply rapidly and have huge spines, they limit the movement of larger mammals like deer. Barberry also grows yellow flowers and red berries that birds love to eat, who will then carry the seeds to new locations.  

A study that was done in Connecticut found that if there are large amounts of Japanese Barberry bushes there is a higher chance of ticks being there. Ticks can die from dehydration if the humidity is lower than 80%. Since the Japanese Barberry has a higher density foliage than most native plants, it can hold a high humidity level which makes it the best place for a tick to be. Normally ticks are active for 15-16 hours, but since Barberry bushes give ticks protection, they are active for 23-24 hours making it more likely to get bitten by ticks. Not only are Barberry bushes a nursery for ticks, but it is also a nursery for white footed mice and other rodents which are also one of the main food sources for ticks, and reservoirs for Lyme disease. 

 In addition to harboring ticks, Japanese Barberry is an invasive plant by changing the pH of the soil to be more basic native plants, like the blueberry bush will start to get pushed out of its own environment. 

On October 8th, 2021, Pennsylvania added Japanese Barberry onto the noxious weeds list meaning that this plant has been deemed harmful and can no longer be sold or planted. It is very rare that a commonly sold plant would be placed on the noxious weed list. As of right now, there are only  60 plants on this list. Though this ban was placed in 2021, it will take two years to allow nurseries and landscaping companies to remove Barberry bushes from their stock and find replacements. 

If a Barberry is spotted it is best to remove the bush as soon as possible. Japanese Barberries can be very difficult to remove. With thick gloves the smaller Barberry bushes can be pulled out. If they are larger bushes they will have to be dug up. Make sure that the roots are completely removed otherwise they will be able to regrow. 

https://www.invasivespeciesinfo.gov/terrestrial/plants/japanese-barberry

https://www.nl-nhcc.com/images/pdfs/japanese_barberry.pdf

https://prdagriculture.pwpca.pa.gov/Plants_Land_Water/PlantIndustry/NIPPP/Pages/Controlled-Plant-Noxious-Weed.aspx

https://www.dcnr.pa.gov/GoodNatured/pages/Article.aspx?post=116

https://ohioline.osu.edu/factsheet/anr-0106

What if ticks went extinct?

Ticks are known to be blood sucking parasites that transmit various diseases to their host. Even though many people despise ticks, they do play an important role in the ecosystems they live in. 

One species of tick, Deinocroton Draculi also known as “dracula’s terrible tick,” is believed to have been around during the prehistoric time period. It is believed that the Deinocroton fed on the blood of a feathered dinosaur since it was found preserved in Burmese Amber with a feather. Deinocroton went extinct around 99 million years ago and is the only known species of tick that has become extinct. 

Scientists have been able to see how well an ecosystem is doing through ticks. If a tick population is low in an area, that could indicate that predators of smaller animals are out of control. Ticks are great meals for a variety of animals like chickens, turkeys, ducks, quail, frogs, spiders, fire ants, and many more. Without ticks, the animals that primarily eat ticks would become extinct. This will then start a chain reaction where other animals become endangered and extinct. 

Due to the reduction or elimination of deer’s predators like coyotes and bobcats, deers have become over populated. The population of deer has grown to over 30 million in the last 100 years. Deer have been one of the main food sources for ticks, and without ticks deer population would increase even more. Car crashes caused by deers will become more frequent. Vegetation will also start being eaten away, leaving many animals without a home like the forest songbird. Western New York Letchworth State Park lost most of its plants and trees, and cannot regenerate due to the abundance of deers. Scientists at NPS and Schoodic Institute at Acadia National Park in Maine studied the conditions of forests in 39 national parks. The scientists found that 27 out of 39 of the forests in the national parks are in danger due to the excessive amount of white tailed deer. 

A massive loss of vegetation would throw off our global climate, making it more arid. Trees play a huge role in the water cycle by absorbing the rain water and distributing it through its leaves, once the water reaches the leaves some of the water will evaporate into the air. When trees absorb the water they also help filter the water from any excess sediment, nutrients, and toxins before the water enters any waterways. Without trees, serious drought would start to happen and animals would start to die. When rain would come it would become disastrous flooding resulting in tons of land being lost to the ocean. Plants help stop erosion, and with them gone coral reefs and other marine habitats would be smothered. Without plants to provide oxygen, carbon dioxide would become more present in the atmosphere making the air unbreathable.

Mice would also become more rampant without ticks feeding off of them. Mice spread diseases like leptospirosis, salmonella, and tularemia though it won’t be spread through a blood sucking parasite. These diseases would be transmitted through the mouse’s fecal matter, urine, and saliva. Everything from the surfaces we cook on to the air we breathe would be contaminated by mice, resulting in a lot of people getting sick. In order to keep their teeth in decent shape, mice will chew different materials like wood, plastic, soft vinyl, and rubber. If mice did enter your house, it could cause a great deal of damage by chewing through wires and insulation. 

Though ticks can be quite annoying especially when they bite you or a loved one, they do play an important role in the animal kingdom. Ticks help keep different ecosystems in balance, so animals like deer and mice do not destroy the world. 

Can this new pill make you impervious to ticks?

Every year about 476,000 people in the US are diagnosed and treated for Lyme disease, though the Center for Disease Control and Prevention suggests this number may be overestimated due to those treated for a tick bite before a confirmed infection. If a tick is found on a person or an animal, it is important to get the tick tested to know if the tick had any pathogens that could have been transmitted to the host, and if they would need to go to a physician or veterinarian to get treated for that tick-borne illness. 

Since 2016, there has been a chewable tablet for dogs that will kill the tick upon the bite. A similar product may be available to humans in the near future. Today’s tick prevention practices involve wearing long, light-colored clothing to quickly spot crawling ticks, applying chemical repellents, and avoiding tall grass during active tick seasons. Despite continued public health awareness efforts and an expanding shelf of consumer repellents, the rate of tick-borne illnesses has doubled since 2000.  

In California, Tarsus Pharmaceuticals has been testing a pill that is a formulation of  lotilaner, also known as TP-05 which would paralyze and kill a tick by interfering with the way that signals are passed through the tick’s nerve cells. This medicine will work as soon as the tick starts sucking on the blood of the host.

“TP-05 is a tablet designed to prevent Lyme disease by killing ticks before ticks can infect us,” CEO Dr. Bobby Azamian clarified. 

Tarsus first developed lotilaner in July 2023, as an eye drop for humans to treat Demodex blepharitis, which is an inflammation of the eyelid caused by tiny mites. This treatment is called Xdemvy and it would stun the tiny mites that were on the eyelid. Lotilaner was also used to control fleas on cats and dogs. Azamian and his team presented the idea to test lotilaner on people to stop the transmission of diseases by ticks.  

Phase II trial was held in Boston, where they gave 31 healthy adults the pill. Some patients were given a high dose, some a low dose, and some a placebo. A sterile nymph tick was then placed on each of the patient’s arms. After 24 hours of taking TP-05, 97% of the ticks on the high dose patients died, 92% of the ticks on the low dose patients died, and 5% of the ticks on the placebo patients died. None of the patients suffered from severe adverse effects and no major side effects. 30 days after the patients took the pill, a sterile nymph tick was placed on their arms. 89% to 91% of ticks on the high and low dose patients died, while 9% of the ticks died on the placebo patients. 

Tarsus Pharmaceuticals states that since the pill kills the tick completely and not just a specific disease, it could stop the transmission of more than just Lyme disease. It suggests the pill could potentially stop other tick borne pathogens like anaplasmosis and Borrelia miyamotoi from being transmitted to humans. TP-05 could possibly be taken the night before going into a tick infested area. “This pill is potentially pre-exposure prophylaxis that you don’t have to think about,” says Linden Hu.

Tarsus Pharmaceuticals hopes TP-05 is ready by the year 2026. Though this pill has shown great success in killing the tick, it still does not answer their original question of whether there could be a pill that would stop the transmission of Lyme disease. For Tarsus to truly know that, it would have to be tested on hundreds of people who are at high risk of contracting the disease. 

Tarsus Pharmaceuticals is not the only one trying to create medicine that could kill ticks before they bite. Pfizer has been developing a shot called VLA15 that will stop the transmission of Lyme disease.They plan to file for a FDA approval for the Lyme disease shot in 2025. 

Pfizer started Phase III in August 2023. The testing was designed for 18,000 healthy people, but only 7,000 people have enrolled so far. During the testing 3,500 people were pulled from Phase III due to violations of good clinical practice or GCP by a third party clinical trial operator. It is unknown which GCP rule was broken, but Pfizer has made it clear that it is not due to safety concerns and was not prompted by an adverse event. Currently, Pfizer is preparing to finish Phase III by the end of 2024, but there might be some delays because of the thousands of people pulled from the trial.